The Effects of 6-Chromanol SUL-138 during Hypothermic Machine Perfusion on Porcine Deceased Donor Kidneys

Diminishing ischemia-reperfusion injury (IRI) by improving kidney preservation techniques offers great beneficial value for transplant recipients. Mitochondria play an important role in the pathogenesis of IRI and are therefore interesting targets pharmacological interventions. Hypothermic machine perfusion (HMP), as a strategy, possibility to provide mitochondrial–targeted therapies. This study focuses on addition mitochondrial protective agent SUL—138 during HMP assesses its effect function normothermic reperfusion. In this case, 30 min warm ischemia was applied porcine slaughterhouse kidneys before 24 h non–oxygenated with or without SUL—138. Functional assessment performed 4 autologous blood No differences renal parameters were found between both groups. ATP levels lower after SUL–138 group (n.s, p = 0.067) but restored significantly combination Aspartate aminotransferase (ASAT) group. does not influence model. Restoration SUL ASAT could be indication improved function.